Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development.
Identifieur interne : 001923 ( Main/Exploration ); précédent : 001922; suivant : 001924Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development.
Auteurs : Lanying Du [États-Unis] ; Guangyu Zhao ; Zhihua Kou ; Cuiqing Ma ; Shihui Sun ; Vincent K M. Poon ; Lu Lu ; Lili Wang ; Asim K. Debnath ; Bo-Jian Zheng ; Yusen Zhou ; Shibo JiangSource :
- Journal of virology [ 1098-5514 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Anticorps neutralisants (sang), Coronavirus (génétique), Coronavirus (immunologie), Coronavirus (métabolisme), Dipeptidyl peptidase 4 (métabolisme), Glycoprotéine de spicule des coronavirus (génétique), Glycoprotéine de spicule des coronavirus (immunologie), Glycoprotéine de spicule des coronavirus (métabolisme), Humains, Infections de l'appareil respiratoire (virologie), Infections à coronavirus (virologie), Lignée cellulaire, Récepteurs viraux (métabolisme), Sites de fixation, Souris, Souris de lignée BALB C, Structure tertiaire des protéines, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie).
- MESH :
- génétique : Coronavirus, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- immunologie : Coronavirus, Glycoprotéine de spicule des coronavirus, Vaccins antiviraux.
- métabolisme : Coronavirus, Dipeptidyl peptidase 4, Glycoprotéine de spicule des coronavirus, Récepteurs viraux.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- Animaux, Humains, Lignée cellulaire, Sites de fixation, Souris, Souris de lignée BALB C, Structure tertiaire des protéines.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Binding Sites, Cell Line, Coronavirus (genetics), Coronavirus (immunology), Coronavirus (metabolism), Coronavirus Infections (virology), Dipeptidyl Peptidase 4 (metabolism), Humans, Mice, Mice, Inbred BALB C, Protein Structure, Tertiary, Receptors, Virus (metabolism), Respiratory Tract Infections (virology), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology), Spike Glycoprotein, Coronavirus (metabolism), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- genetics : Coronavirus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- immunology : Coronavirus, Spike Glycoprotein, Coronavirus, Viral Vaccines.
- metabolism : Coronavirus, Dipeptidyl Peptidase 4, Receptors, Virus, Spike Glycoprotein, Coronavirus.
- virology : Coronavirus Infections, Respiratory Tract Infections.
- Animals, Binding Sites, Cell Line, Humans, Mice, Mice, Inbred BALB C, Protein Structure, Tertiary.
Abstract
A novel human Middle East respiratory syndrome coronavirus (MERS-CoV) caused outbreaks of severe acute respiratory syndrome (SARS)-like illness with a high mortality rate, raising concerns of its pandemic potential. Dipeptidyl peptidase-4 (DPP4) was recently identified as its receptor. Here we showed that residues 377 to 662 in the S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP4 protein and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as a MERS-CoV vaccine.
DOI: 10.1128/JVI.01048-13
PubMed: 23824801
Affiliations:
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Dipeptidyl peptidase-4 (DPP4) was recently identified as its receptor. Here we showed that residues 377 to 662 in the S protein of MERS-CoV specifically bound to DPP4-expressing cells and soluble DPP4 protein and induced significant neutralizing antibody responses, suggesting that this region contains the receptor-binding domain (RBD), which has a potential to be developed as a MERS-CoV vaccine. </div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Debnath, Asim K" sort="Debnath, Asim K" uniqKey="Debnath A" first="Asim K" last="Debnath">Asim K. Debnath</name><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><name sortKey="Kou, Zhihua" sort="Kou, Zhihua" uniqKey="Kou Z" first="Zhihua" last="Kou">Zhihua Kou</name><name sortKey="Lu, Lu" sort="Lu, Lu" uniqKey="Lu L" first="Lu" last="Lu">Lu Lu</name><name sortKey="Ma, Cuiqing" sort="Ma, Cuiqing" uniqKey="Ma C" first="Cuiqing" last="Ma">Cuiqing Ma</name><name sortKey="Poon, Vincent K M" sort="Poon, Vincent K M" uniqKey="Poon V" first="Vincent K M" last="Poon">Vincent K M. Poon</name><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Du, Lanying" sort="Du, Lanying" uniqKey="Du L" first="Lanying" last="Du">Lanying Du</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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